![]() In the unadjusted analysis, higher VAT was associated with greater impairment in E cc. ![]() The study included 1089 participants (55% female, 39% black). The cross-sectional associations of measures of regional adiposity, namely visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and lower-body fat (LBF) with E cc after adjustment for CRF and other potential confounders (independent variables) were assessed using multivariable linear regression analysis. Participants from the Dallas Heart Study Phase 2 who underwent dual energy X-ray absorptiometry assessment of regional fat distribution, CRF assessment by submaximal treadmill test, and E cc quantification by tissue-tagged cardiovascular magnetic resonance were included in the analysis. ![]() However, the association of regional fat distribution and CRF with E cc independent of each other and other potential confounders is not known. Low cardiorespiratory fitness (CRF), high body mass index, and excess visceral adiposity are each associated with impairment in left ventricular (LV) peak circumferential strain (E cc), an intermediate phenotype that precedes the development of clinical heart failure (HF).
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